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Evidence Based Medicine
The Power of Placebo: Can They Be As Effective As Treatments?
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The Power of Placebo: Can They Be As Effective As Treatments ?

Seper Ekhtiari

et al.

Click here to list additional authors

/ May 7, 2023
This OE Insight examines the evolving science of the placebo effect, tracing its history from 18th-century origins to modern neurobiological and surgical applications. Placebos can trigger real physiological responses—like endogenous opioid release—and influence outcomes via color, branding, and route of administration. Surgical trials present unique challenges, especially around ethics and informed consent. The authors advocate for thoughtful, transparent use of placebo controls to strengthen clinical evidence while preserving patient trust.

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  • Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
  • Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
  • Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
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OrthoEvidence. The Power of Placebo: Can They Be As Effective As Treatments?. OE Original. 2023. Available from: https://myorthoevidence.com/Original/Show/the-power-of-placebo-can-they-be-as-effective-as-treatments

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