Showing 1 - 12 of 371 reports matching: Osteoarthritis
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Synopsis: 12 patients with bilateral knee osteoarthritis had one knee randomized to injection with 20mg triamcinolone hexacetonide, and the other knee randomized to injection with saline. The purpose of this study was to compare pain, knee stiffness & tenderness, patient preference, and thermographic indices between knees over a 6-week follow-up. While reporting of Read More »
Level 2 RCT
Synopsis: 16 patients (24 knees) with knee osteoarthritis were randomized to an injection with either 20mg triamcinolone hexacetonide or placebo. After 1 week, patients initially administered a triamcinolone hexacetonide injection received a saline injection, and patients initially administered a saline injection received a triamcinolone hexacetonide injection. Patients were assessed Read More »
Level 2 RCT
Synopsis: 77 patients with knee osteoarthritis underwent knee arthroscopy & joint lavage, followed by an intra-articular injection of corticosteroid (120mg methylprednisolone acetate) or placebo saline, assigned randomly. The outcomes assessed included patient-reported pain and function, response rate (minimum 30% reduction in pain from baseline), and relapse rate at 2, 4, 8, 12, and 24-week follow-ups. Results demonstrated no Read More »
Level 2 RCT
Synopsis: 25 patients with a total of 38 knees with osteoarthritis were randomized to the order in which they received either hydrocortisone tert-butylacetate, hydrocortisone acetate, or placebo injections. For each treatment, four injections were given, every 2 weeks. A washout period Read More »
Level 2 RCT
Synopsis: 120 patients with knee osteoarthritis were randomized to a single intra-articular injection of either 40mg triamcinolone acetate, 3mg betamethasone disodium phosphate, 40mg methylprednisolone acetate or placebo. Patients were followed at 1, 3, 6, and 12 weeks after injection for pain reduction on a visual analog scale and functional improvement on the Lequesne Functional Index. Results demonstrated significantly Read More »
Level 2 RCT
Synopsis: 62 patients with medial knee osteoarthritis or osteonecrosis who were scheduled for opening-wedge high tibial osteotomy were randomized to the procedure using either combined CT-based and image-free navigation technology or conventional techniques to create the correction angle. The primary purpose of this study was to evaluate if navigation allowed for fewer coronal and sagittal outliers on postoperative computed tomography (CT). No significant difference Read More »
Level 2 RCT
Synopsis: Twenty randomized controlled trials (RCTs) were included in a meta-analysis and systematic review comparing pain, treatment-emergent adverse events, and function between Hylan G-F 20 injections and low-molecular-weight hyaluronic acid (LMWHA) injections for knee osteoarthritis. No significant differences between products were observed in pain overall or the incidence of treatment-emergent related adverse events. When subgrouped based Read More »
Level 1 Meta Analysis
Synopsis: 120 patients with K-L grade III knee osteoarthritis were randomized to receive either glucosamine sulfate or a combination of methylsulfonylmethane and boswellic acids. The purpose of the study was to determine if the dual agent treatment was superior to the routinely used glucosamine sulfate in terms of pain and function outcomes. The findings of Read More »
Level 2 RCT
Synopsis: Ten randomized controlled trials (645 patients) were included in this meta-analysis to determine the effect of therapeutic ultrasound in the management of knee osteoarthritis when compared to sham or no-intervention. The pooled results of this meta-analysis indicated that therapeutic ultrasound significantly reduced pain and improved function compared to sham treatment. Additionally, few adverse Read More »
Level 1 Meta Analysis
Synopsis: 47 patients with knee osteoarthritis were randomized to one of two injection therapy groups; one group received two courses of three weekly sodium hyaluronate injections, with the addition of a corticosteroid injection at the beginning of each course, while the second group was treated with the two course of sodium hyaluronate injections alone. Patients were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and a 100mm visual analog scale for pain at 1, 2, 3, 6, 7, 9, and 12 months, as well as on magnetic resonance imaging (MRI) at 12 months. Results demonstrated significant Read More »
Level 2 RCT
Synopsis: 98 patients with knee osteoarthritis were randomized to an intra-articular injection of Hydros hyaluronic acid, Hydros plus 10mg triamcinolone acetonide (Hydros-TA), or Synvisc-One hyaluronic acid. The purpose of this study was to compare the effects of Hydros hyaluronic acid, with or without the addition of corticosteroid, to Synvisc-One for patient-reported pain and functional improvement after 2, 6, 13, and 26 weeks using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results demonstrated no Read More »
Level 2 RCT
Synopsis: 98 patients with knee osteoarthritis were randomized in a 2x2 factorial design to receive treatment with either joint lavage plus intra-articular (IA) corticosteroid injection, joint lavage plus IA placebo injection, IA corticosteroid injection alone, or IA placebo injection alone. Patients were followed-up for pain, function, and patient global assessment at 1, 4, 12, and 24 weeks. No significant interaction Read More »
Level 2 RCT