Showing 1 - 12 of 231 reports matching: General Orthopaedics
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Synopsis: 25 randomized controlled trials (RCTs) investigating the safety of direct oral anticoagulants and low molecular weight heparin/fondaparinux in antithrombotic prophylaxis during total hip replacement, total knee replacement, and hip fracture surgery were included. This meta-analysis was conducted in order to determine if direct oral anticoagulants, in addition to the more convenient oral administration and potentially increased compliance rates, are able to provide an enhanced safety profile. The findings of Read More »
Author verified Level 1 Meta Analysis
Synopsis: 849 patients with chronic low back pain (equal or > 3 months) were randomized to receive three intravenous injections of 10 mg or 20 mg of tanezumab followed by up to 4 subcutaneous injections every 8 weeks. This extension study aimed to compare the long-term safety and effectiveness of two different tanezumab doses. Ten and 20 Read More »
Level 2 RCT
Synopsis: 40 patients (24 adults and 16 children) with fibrous dysplasia (FD) were randomized to either receive alendronate administration in 6-month cycles for 24 months or placebo. The results revealed that in the alendronate group, NTX-telopeptides markers significantly declined at 18 months, however no significant difference in osteocalcin was observed between groups. Furthermore, areal bone Read More »
Level 2 RCT
Synopsis: 129 postmenopausal women with low bone mass were randomly assigned to receive either salmon calcitonin orally or placebo once daily for 1 year. The outcomes of interest were the change in bone mineral density (at the lumbar spine, femoral neck, trochanter, and total hip) and collagen type 1 C-telopeptide (CTx-1). The findings demonstrated Read More »
Level 2 RCT
Synopsis: 60 male patients, 30 with and 30 without opium addiction, who were scheduled to undergo lower limb orthopaedic surgery were randomized to receive spinal anesthesia (bupivacaine) with or without sufentanil. The purpose of this study was to compare the duration and onset times of sensory and motor blocks between four patient groups: patients with no history of opium addiction who were given placebo (1) or sufentanil (2) and chronic opium users who were given placebo (3) or sufentanil (4). Results demonstrated that Read More »
Level 2 RCT
Synopsis: 40 patients with hip pain were randomized to receive an ultrasound-guided intra-articular corticosteroid injection with or without the use of an automated delivery system. The objective of this trial was to determine if the automated delivery was associated with significantly superior clinical efficiency when compared to a traditional injection technique. Outcome measures were Read More »
Level 2 RCT
Synopsis: 571 elderly patients who sustained a low-energy trauma with suspected hip fracture were randomized to receive either prehospital fast track care (PFTC) or traditional emergency room (A&E) care. The purpose of this study was to determine whether a newly introduced treatment pathway (PFTC) would be more beneficial in outcomes such as time to surgery, hospital stay duration, postoperative complications, and mortality. Findings indicated no Read More »
Level 2 RCT
Synopsis: 36 patients undergoing bilateral tibial lengthening were included in this study to determine what effects botulinum toxin A (BtX-A) injections have on calf pain, swelling, and knee & ankle range of motion following limb lengthening. Patients had one leg randomized to a control group, which was injected with saline solution, and the other leg randomized to an intervention group, which was injected with 200 IU of BtX-A. A handheld dynamometer, Read More »
Level 2 RCT
Synopsis: 101 patients undergoing orthopaedic surgery below the shoulder were randomized to receive ultrasound guided brachial plexus block through a supraclavicular, infraclavicular, or axillary approach. The purpose of this study was to determine if there were significant differences in block performance time, quality of nerve block, or proportion of failed blocks when comparing anaesthetic approaches up to thirty minutes after surgery completion. Results demonstrated that Read More »
Author verified Level 2 RCT
Synopsis: 130 patients undergoing bone substitution implantation were randomized to one of two synthetic porous composite groups for the purpose of comparing the efficacy and safety throughout a 24-week period: (1) porous hydroxyapatite/collagen composite (HAp/CoL) or (2) porous beta-tricalcium phosphate (beta-TCP). Results demonstrated that a significantly larger proportion of patients in the HAp/CoL had "highly effective" implants and regeneration when compared to the beta-TCP group at 18 and 24 weeks. However, the number Read More »
Level 2 RCT
Synopsis: 126 patients with patellofemoral joint (PFJ) osteoarthritis (OA) were randomized to either a knee support brace, or a control group without brace support for 6 weeks. The purpose of this study was to determine the effects of a flexible knee brace on quadriceps maximum voluntary contraction (MVC) and athrogenous muscle inhibition (AMI) in PFJ OA patients. Patients in the Read More »
Level 2 RCT
Synopsis: 15 randomized controlled trials comparing electrical stimulation to sham treatment in adults with a fresh fracture, nonunion, delayed union, osteotomy, or symptomatic spinal instability requiring fusion were included. The purpose of this meta-analysis was to quantitatively assess the efficacy of bone stimulation in terms of pain relief, functional improvements, and radiographic nonunion. The results indicated Read More »
Author verified Level 1 Meta Analysis